Aztreonam side effects, dosage, interactions drugs. Aztreonam is used to treat severe infections of the blood, urinary tract, lungs, skin, stomach, or female reproductive organs. Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. Azactam may be used in the treatment of infections present in various parts of the body and sometimes azactam is given with other antibiotics. Specific dosing recommendations for patients with renal insufficiency are in the dosage and administration section of the full prescribing information. The renal drug handbook the st georges hospital, adult critical. Azactam information, side effects, warnings and recalls. Although data are lacking, the fdaapproved labeling states that nitrofurantoin is contraindicated in patients with anuria, oliguria, or severe renal impairment where crcl is less than 60 mlminute and extreme caution is warranted in other patients with renal disease.
Renal status is a major determinant of dosage in the elderly. Atracurium, auranofin, azatadine, azathioprine, azithromycin, aztreonam, benazepril, bepridil, betamethasone, betaxolol, bezafibrate, bisoprolol, bleomycin. The elimination of ceftazidime by the kidneys resulted in high therapeutic concentrations in the urine. For seizure indication, administer q12h but may require. Aztreonam injection azactam side effects, medical uses. Dosing guidelines book school of medicine university of. Aztreonam is a monocyclic betalactam monobactam antibiotic with an antibacterial spectrum limited to gramnegative aerobic bacteria including pseudomonas aeruginosa, neisseria meningitidis, and haemophilus influenzae. Cvvhd removes solutes including drugs via diffusion. Effect of hemodialysis and peritoneal dialysis on aztreonam pharmacokinetics. Find information on aztreonam azactam, cayston in daviss drug guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Dosage adjustment due to renal impairment is necessary for systemic dosage only.
This may include bone infections, endometritis, intra abdominal infections, pneumonia, urinary tract infections, and sepsis. Please also see full prescribing information for azactam. Your doctor may have prescribed azactam for another use. Azactam injection aztreonam dose, indications, adverse. Azactam dosage guidelines for pediatric patients type of infection dose frequency hours maximum recommended dose is 120 mgkgday.
Clinical cure rate in patients with normal renal functionmild renal impairment crcl greater than 50 mlmin was 85% 322379 with avycaz plus metronidazole vs 86%. Aztreonam is an antibiotic recommended in an inhaled solution form for cystic fibrosis cf patients with infections due to the pseudomonas aeruginosa p. This emedtv web selection offers an indepth look at this medication, including specific uses, possible side effects, dosing information, and more. Effect of hemodialysis and peritoneal dialysis on aztreonam. The recommendations in this online publication do not indicate an exclusive course of treatment or serve as a standard of medical care. Visit athenainsight for proven, replicable best practices and datadriven strategies to enhance your practices performance. Kathy robinson, university of north carolina school of medicine answered may. Nebulized aztreonam does not require dosage adjustment due to low systemic exposure. Therefore, the dosage of azactam should be halved in patients with estimated creatinine clearances between 10 and 30 mlmin1. Dosing guidelines for adults and children book online at best prices in india on. Atenolol, atracurium, azathioprine, azithromycin, aztreonam, bisoprolol, bumetanide, busulfan, caffeine, captopril, carbamazepine, carboplatin, carmustine. What are the possible side effects of aztreonam azactam. The serum halflife of aztreonam averaged 1,7 hours 1,5 to 2,0 in subjects with normal renal function, independent of the dose and route of administration. Azactam 1g powder for solution for injection or infusion, vial summary of product characteristics.
All of the above doses of azactam result in average urine levels of aztreonam which exceed the mic 90 for the same pathogens for up to 12 hours. Dosage and route of administration should be determined by susceptibility of the causative. Aztreonam for inhalation solution aztreonam antibiotic. Dilute 500 mg parenteral cefazolin powder in sterile water to form 10 ml solution. Dosing renal impairment avycaz ceftazidime and avibactam. Your doctor will monitor your condition and blood work as needed.
In patients with impaired renal function, the serum halflife of aztreonam is prolonged. After a normal loading dose, administer 50% of the standard dose and give at standard dosing intervals. Avycaz ceftazidime and avibactam, in combination with metronidazole, is indicated for the treatment of complicated intraabdominal infections ciai in adults and. Comprehensive update to antimicrobial renal dosing document. In elderly patients, the mean serum halflife of aztreonam increased and the renal clearance decreased, consistent with the agerelated decrease in creatinine clearance. Azactam and other antibacterial drugs, azactam should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Prolonged serum levels of aztreonam may occur in patients with transient or persistent renal insufficiency. Azactam 1 g powder for solution for injection or infusion. The mean renal clearance of ceftazidime was approximately 100 mlmin. If aztreonam skin test results are negative, the patient can receive it by graded challenge. Can azactam aztreonam injection cause decreased renal.
Analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. For hd, draw trough prehd, and peak 30 min after end of each infusion streptococci, streptococcus bovis, strep. Compare prices, print coupons and get savings tips for azactam aztreonam and other skin infection, urinary tract infection, bacterial infection, lower respiratory infection, and gastrointestinal infection drugs at cvs, walgreens, and other pharmacies. Variations, taking into account individual circumstances, may be appropriate. The dosage is based on your medical condition and response to therapy. Do not treat diarrhea with over the counter products. Aztreonam is an fda pregnancy category b drug and lacks crossallergenicity with. When a patient is initiated on crrt, antimicrobial therapy often requires adjustment to ensure adequate drug concentrations are achieved. Aztreonam is a topic covered in the johns hopkins abx guide. The information on dosage adjustments in renal impairment given in this book is based on. Detailed aztreonam dosage information for adults and children. Macrobid nitrofurantoin macrocrystalsnitrofurantoin.
The serum halflife of aztreonam averaged 1,7 hours 1,5 to 2,0 in subjects with normal renal function, independent of. The fdalabeled dosage adjustment in adults with renal impairment reduces the dose and maintains the fixed dosing intervals. Cf is caused by a defect in the cystic fibrosis transmembrane conductance regulator cftr protein, which leads to impairment in the normal function of the lungs and pancreas. Azactam 1g powder for solution for injection or infusion. If aztreonam skin tests to aztreonam are positive and the patient has a particular need for. Aztreonam is a topic covered in the johns hopkins abx guide to view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. Renal dosage adjustment guidelines for antimicrobials. Jan 31, 2019 the dose range of azactam is 1 to 8 g daily in equally divided doses.
Can azactam aztreonam injection cause decreased renal function in elderly. Consumer medicine information cmi about azactam aztreonam intended for persons living in australia. Consumer information about the medication aztreonam injection azactam, includes side effects, drug interactions, recommended dosages, and storage information. Simplified aztreonam dosing in patients with endstage renal disease. Administer im injections into large muscle and rotate sites. Jun 03, 2019 what are the possible side effects of aztreonam azactam. Azactam aztreonam injection the structural difference. Azactam 2 g powder for solution for injection or infusion.
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling. Renal dosage adjustment guidelines for antimicrobials the pharmacists will automatically adjust the doses of any of the antimicrobials included in the protocol according to the estimated creatinine clearance generally using the cockroftgault equation for patients. In patients treated with an aminoglycoside and azactam, monitor renal function for potential nephrotoxicity and ototoxicity of aminoglycosides. Aztreonam, a new monobactam, will be widely used because of its broad aerobic gramnegative bacterial coverage and its apparent low risk of allergic phenomena in penicillincephalosporinsensitive patients.
It was originally isolated from chromobacterium violaceum. There are insufficient data regarding intramuscular administration to pediatric patients or dosing in pediatric patients with renal impairment. There is insufficient information to recommend a dosing regimen for pediatric patients 60. To view the entire topic, please sign in or purchase a subscription. Dosing guidelines book dosing guidelines for children dosing guidelines for adults. For oncedaily dosing, draw a single random level 8 to 12 hours after dose given adjustments are made based on a published hartford nomogram. Azactam aztreonam for injection, usp contains the active ingredient aztreonam, a monobactam. Normal dose based on indication, titrate according to target serum level. An additional 20% was excreted between two and four hours after dosing, and approximately another 12% of the dose appeared in the urine between four and eight hours later. Welcome to the fifth edition of the renal drug handbook. Azactam aztreonam dosing, indications, interactions. Azactam injection aztreonam injection side effects. Read more about the prescription drug aztreonam injection.
Azactam is available in two strengths and each vial contains either 1g or 2g aztreonam as a powder for solution for injection or infusion. Within this subgroup, patients treated with avycaz received a 33% lower daily dose than is currently recommended for patients with crcl of 30 to less than or equal to 50 mlmin. Gerig js, bolton nd, swabb ea, scheld wm, bolton wk. This medication is usually given by injection into a vein or a muscle as directed by your doctor. Aztreonam systemic drug monograph pediatric care online. The dosage and route of administration should be determined by the susceptibility of the causative organisms, severity of infection and the condition of the patient. Aztreonam, sold under the brand name azactam among others, is an antibiotic used primarily to treat infections caused by gramnegative bacteria such as pseudomonas aeruginosa. Azactam injection aztreonam injection side effects, images. Official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. Simplified aztreonam dosing in patients with endstage renal. Azactam should be administered intravenously to pediatric patients with normal renal function.
143 1103 861 328 229 750 300 1363 567 252 783 125 412 910 158 518 1144 1287 718 1330 1644 1400 237 479 1024 474 633 773 32 358 236 50 120 1189 266 463 148 1387